Screening and Evaluation of Lactobacillus Strains for Improving Metabolic Syndrome
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Abstract:
In order to screen the lactic acid bacteria that can relieve the metabolic syndrome, a mouse model with metabolic syndrome was established using high-fat and high-fructose diet. The body weight, serum lipid levels, inflammatory factors, and insulin resistance index were detected to evaluate the effects of six strains of Lactobacillus on improving metabolic syndrome. The results of APICHL50 sugar fermentation and 16S rDNA partial sequence alignment results showed that six strains of Lactobacillus were identified as Lactobacillus plantarum. Furthermore, compared with the model group, all the strains could reduce body weight, regulate lipid disorders, down-regulate inflammation levels, improve insulin resistance. However, there were obvious differences in the functions among six strains. Our results indicated that L. plantarum S9 could obviously improve the insulin resistance index (29.26%), markedly decrease TC (13.22%), TG (9.97%), LDL-C (21.31%) and FFA (32.33%) levels and increase HDL-C (15.91%) in serum. Moreover, L. plantarum S9 could significantly decline the inflammatory factor levels in serum (IL-1β 12.03%, TNF-α 20.46%, IL-6 15.90%, CRP 37.28%, LPS 10.01%). Therefore, all above results imply that L. plantarum S9 can be used as a potential functional strain for the prevention and treatment of metabolic syndrome.
