Resveratrol Improved the Immune Function of Rats Exposed to T-lymphocyte Injury Induced by Samray
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Abstract:
To study the effect of resveratrol on immune function of rats exposed to t-lymphocyte injury induced by tpa, 50 SPF-level SD healthy rats were randomly divided into blank group, model group, low-dose group (20 μmol/L), medium-dose group (40 μmol/L) and high-dose group (80 μmol/L), to establish the tlymphocyte injury model rats induced by γ-ray. After successful modeling, rats were given resveratrol by gavage. According to the experimental design, the proliferation rate of T cells, nuclear factor kB of T lymphocytes (NF-kB) expression, level of T lymphocytes (CD3, CD4, CD8), interferon-γ (IF-γ), interleukin-12 (IL-12), interleukin-4 (IL-4), and interleukin-3 (IL-3) were detected. The results showed that the proliferation rate, CD3, CD4, CD8 and CD4/CD8 of resveratrol group (40 μmol/L) were 2.15%, 54.15%, 35.11%, 21.45% and 2.11, respectively. The levels of IF-γ, IL-12, IL-4 and IL-3 secreted by T cells were 21546.15 pg/mL, 212.15 pg/mL, 645.56 pg/mL and 221.15 pg/mL, respectively, which were significantly different from those of other experimental groups (p<0.05). It is understood that resveratrol can significantly inhibit and regulate T cells and improve the immune function of rats.
