Protective Effect of Ginseng Polysaccharide on Mitochondria in Rats with Coronary Heart Disease
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Abstract:
The protective effect of ginseng polysaccharide on mitochondria in rats with coronary heart disease was studied. The levels of mitochondrial calcium (Ca2+), succinate dehydrogenase (SDH), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), soluble Fas (FAS), Fas ligand (FASL), b-lymphoma-2 (Bcl-2) and b-lymphoma-2 genes related X protein (Bax) were detected by the intervention of ginseng polysaccharide. The results showed that the concentration of Ca2+ and SDH activity were significantly changed with the increase of the action concentration of ginseng polysaccharide (p<0.05), among which, the Ca2+ concentration and SDH activity in the high dose group were 43.41 μmol/g and 7.21 U/mg respectively. After the action of ginseng polysaccharide, MDA content, GSH PX enzyme activity and SOD activity in high dose group were 4.19 nmol/mL, 132.42 U/mg and 90.18 U/mL respectively, which were significantly different from those in the model group (p<0.05). At the same time, compared with the model group, ginseng polysaccharide significantly reduced the expression levels of FASL, Fas, Bcl-2 and Bax in rats (p<0.05). The expression of FASL, Fas, Bcl-2 and Bax in high dose group was 1.21, 1.09, 1.08 and 1.02, respectively. The results showed that ginseng polysaccharide could improve the blood lipid abnormality in rats with coronary heart disease, and had the function of anti-oxidation and anti-tumor, and had strong protective effect on mitochondria.
