Protective Effects of α-linolenic acid Riched Flaxseed Oil on Suppressing Insulin Resistance and Oxidative Stress in Rats with Polycystic Ovary Syndrome
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Abstract:
In this study, the effects of flaxseed oil (FO) rich in α-linolenic acid (ALA) on insulin resistance and oxidative stress level in polycystic ovary syndrome (PCOS) rats were investigated. The PCOS rat model was established by the letrozole modeling method. After successful modeling, the FO control group and the FO intervention model group were administered with FO by gavage for 8 W, while the negative control group and the model group were fed the same amount of normal saline. After the intervention, the contents of sex hormones, blood lipids, as well as the contents of insulin resistance and oxidative stress indicators of the different groups of rats were detected. The results showed that after the dietary FO intervention, the levels of androgen (T), cholesterol (TC), triglyceride (TG), fasting insulin (FINS), insulin resistance index (HOMA-IR) and malondialdehyde (MDA) decreased to 3.26 nmoL/mL, 1.78 mmoL/mL, 1.45 mmoL/mL, 5.37 mIU/L, 1.22 and 5.33 nmoL/mL, respectively, compared with model group, whilst the levels of estradiol (E2), and antioxidant indices total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD), increased to 26.54 pmoL/mL, 5.11 U/mL, 372.10 enzyme activity unit and 80.29 U/mL, respectively, compared with the model group (p<0.05). This study showed that dietary FO ameliorates insulin resistance and oxidative stress in PCOS rats.
