Structure and Property of Chitosan/Starch Composite Film with Different Kinds of Starch
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Abstract:
To improve the bioavailability of drug or bioactive component, in this work, composite films with 150,000 g/mol chitosan and three different kinds of starch were prepared by casting method. The characteristics were analyzed by FTIR, SEM, tensile test and in vitro releasing test. By the hydrogen bond between -NH3+ of chitosan and -OH of starch, there was formed chitosan/starch composite structure in the film. Due to difference in starch structure, the order of chitosan/starch composite structure was changed, which further affected the mechanical properties, acid resistance and controlled-releasing properties of the film. Results showed that the order of CTS/Potato and CTS/Tapioca composite film structure was better than that of CTS/Corn. The CTS/Potato and CTS/Tapioca composite film also showed a good acid resistance in simulated stomach fluid (film loss at the range of 18.71%~26.15% and 16.14%~19.64%, respectively) and a well-controlled-releasing property of theirs film-coated tablet (about 60% of the model bioactive component releasing in small intestine or colon), which could be potential to bioactive component for small intestine or colon site delivery.
