Comparative Analysis of Antioxidant and Hypoglycemic Capabilities of Taraxacum mongolicum Root Extracts in Different Solvents
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Abstract:
In order to evaluate the active function of extracts from Taraxacum mongolicum root by different solvents, the Taraxacum mongolicum root was used as the raw material in this work. Six solvents, namely water, methanol, ethanol, ethyl acetate, chloroform and hexane were used. The effects of different solvent on the antioxidant activities of extracts were investigated. The effects of different extracts on the α-glucosidase and α-amylase were also studied. The active ingredients in different extracts were analyzed. The results indicated that solvent polarity had a substantial influence on the extraction efficiency of Taraxacum mongolicum root and the antioxidant activities of their extracts. As the polarity of the solvent decreased, the extraction rate and antioxidant activity decreased. The water extract had the highest crude extract yield of 24.87%. Water extract also revealed the best DPPH racial scavenging capacity, the best hydroxyl radicals scavenging capacity, the best ABTS+· scavenging capacity, and the best reducing power. With the concentration increasing, the inhibitory rates of six extracts to α-glucosidase and α-amylase increased. When the concentration reached to 5 mg/mL, the inhibition abilities of α-glucosidase and α-amylase were the strongest under water extraction conditions, reaching 71.56% and 74.9%, respectively. Among the six solvent extracts, the content of polysaccharides in water extraction was highest, and the content was 63.92 mg/g. The content of total flavon and total phenols in the ethanol extract were highest,and the content were 10.03 mg/g and 12.26 mg/g, respectively. The content of saponin in methanol extract was highest, and the value was 0.88 mg/g. By in vitro verification of antioxidant and hypoglycemic capacity assays, the evaluation of the active function of Taraxacum Mongolicum roots will be provide the foundation for their development and application.
