Rapid Evaluation on the Film Coating Effect of Pine Pollen Tablets by Near Infrared Spectroscopy
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Abstract:
In this study, near-infrared diffuse reflection detection technology was used to evaluate he film-coating effect of Guozhen pine pollen tablets and determine whether the tablets reached the coating end point. Fourier transform near infrared spectrometer was used to scan pine pollen tablet samples, and the obtained near-infrared original spectra were pre-treated to eliminate interfering factors using smooth (17 smooth points) + vector normalization + first spectrum pre-processing method. Within 7500~4000 cm-1, Guozhen pine pollen tablet conformity test model was established using OPUS analysis software with the model conformity test index set as 4, The conformity test method was used to establish a conformity determination model of pine pollen tablets to evaluate the film-coating effect of Guozhen pine pollen tablets. The results showed that this method could rapidly evaluate the coating effect of Guozhen pine pollen tablets and determine that 75.6% of Guozhen pine pollen tablets could reach its coating end point when the film coating time was 120 min. This method does not require chemical treatment of the sample and is convenient and fast. The method can rapidly and accurately evaluate the coating effect and determine whether the pine pollen tablets have reached the coating end point, providing a basis for the research on the online detection of the film coating end point of pine pollen tablets.
