Salmon Collagen Oligopeptide Calcium Increase Bone Mineral Density of SD Rat
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Abstract:
Salmon bone collagen oligopeptide was prepared from salmon bone and chelated with calcium ion as salmon collagen oligopeptide calcium and used as test substance. Sprague-Dawley rats were orally administered with low, medium and high doses of test substances, and a blank control group and a calcium carbonate positive control group were used. The body weight, calcium absorption rate and retention rate, femur dry weight, femur length, bone density and other important indicators were measured to evaluate the bone mineral density of the salmon collagen oligopeptide calcium. The results showed that the total protein content of salmon collagen oligopeptide calcium was 65.37%, the chelation rate was 52.56%, and the chelate yield was 43.12±0.13%. There was no significant difference in body weight between the experimental groups (p>0.05). The calcium absorption rates of the middle and high dose groups and the calcium carbonate group were 39.18%, 40.52%, 38.38%, respectively, and the retention rate was 38.80%, 39.27%, 37.58%, respectively, which were significantly higher than the blank control group 36.31, 35.91 (p<0.05), respectively. The high dose group was significantly better than the calcium carbonate group with the same calcium content (p<0.05). In addition, the femoral dry weight and midpoint diameter of the femur were 0.57 (g) and 2.40 (mm), respectively. The proximal, distal and midpoint density of the femur were 0.19, 0.22, 0.17 (g/cm2), respectively. These were higher than that in the blank group (p<0.05) and there was no significant difference from the calcium carbonate group. It indicated that the salmon collagen oligopeptide calcium had a good calcium-absorbing effect and a bone density-enhancing function, which provided a good theoretical foundation for the development and utilization of related new functional foods.
