Effect of Probiotic Intervention Frequency and Cycle on Serum Antioxidant Capacity in Rats with Hyperlipidemi
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Abstract:
In this study, a rat model of hyperlipidemia was established, and the Lactobacillus plantarum 67 with high in vitro antioxidant capacity was preserved separately in the laboratory. According to the “intermittent fasting” method, an intervention with the Lp 67 strain being intervened 5 times per week (the 5 : 2 intervention group) or being intervened once per two days (the every other day intervention group) were established. The levels of serum GSH-Px, T-SOD, CAT and MDA and the T-AOC ability of these two groups were measured in different periods of intervention, and compared with those of the other groups, to explore the influence of probiotic intervention frequency and cycle on the serum antioxidant capacity of hyperlipidemic rats. Compared with the model group, the intervention group had significantly increased levels of serum GSH-Px and T-SOD (p<0.05), significantly decreased MDA level (p<0.05), and insignificantly improved T-AOC ability (p>0.05). The CAT level significantly reduced (p<0.05) for the 5:2 intervention group but insignificantly reduced (p>0.05) for the every other day intervention group. In general, the every other day intervention of the Lp 67 strain continuously for 8 weeks was more effective, which increased the GSH-Px level, T-SOD level, CAT level, and T-AOC ability by 93.08 nmol/mL, 13.05 U/mL, 5.97 U/mL, and 0.50 U/mL, respectively, while decreasing the MDA level by 10.04 nmol/mL. The experimental results showed that the frequency and cycle of probiotic intervention had significant effects on the antioxidant capacity of hyperlipidemic rats.
