Intervention Effect of Momordica grosvenori Extract on Hypothyroidism Model Rats
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Abstract:
The intervention effect and mechanism of Momordica grosvenori extract on hypothyroidism model rats was investigated in this work. Fifty healthy SD rats were selected as normal group, 10 as normal group, and 40 as hypothyroidism model. After successful modeling, the rats were divided into model group, positive control group (1 ml/100 g 0.08% thyroid tablet suspension), low dose group (100 mg/kg Momordica grosvenori extract), high dose group (160 mg/kg Momordica grosvenori extract), 10 rats each. The levels of hypothalamus-pituitary-thyroid axis, hypothalamus-pituitary-gonadal axis factor and the expression of Shh signaling pathway gene were detected. The results showed that the levels of free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), thyroxine (T4), thyrotropin releasing hormone (TRH) in the high dose group increased to 4.25 pmol/L, 16.58 pmol/L, 1.20 nmol/L, 56.35 nmol/L and 4.13 μIU/mL, respectively, and Thyrotropin (TSH) decreased to 1.96 μIU/mL, which was significantly different with other groups (p<0.05). The levels of follicle-forming hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone (P) of female rats in the high-dose group increased to 12.63 IU/L, 14.35 IU/L, 31.24 ng/L and 186.59 ng/L respectively, which were higher than those in the positive control group and the low-dose group (p<0.05). FSH, LH and testosterone (T) increased to 10.25 IU/L, 12.35 IU/L and 369.23 ng/L in the high dose group of male rats, respectively, which were higher than those in the positive control group and the low dose group (p<0.05). The mRNA expression levels of Shh, Patched-1, and Gli-1 in the high-dose group was higher than those of the positive control group and the low-dose group (p<0.05). Momordica grosvenori extract can regulate abnormal thyroid biological effects by acting on Shh signaling pathway, improve thyroid function, increase thyroid hormone secretion, and maintain the dynamic balance of TRH, TSH and thyroid hormone.
