Effect of Chinese Wolfberry Extract on Osteoporosis Rats and Its Mechanism
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Abstract:
In order to explore the improvement effect of Lycium barbarum extract on the symptoms of osteoporosis, this paper discussed the improvement effect of Lycium barbarum extract on the symptoms of osteoporosis in rats through experiments, according to the increase and decrease of the concentration and various indexes of Lycium barbarum extract. Eighty female rats meeting the requirements were divided into two groups, one group for removing ovarian surgery to build osteoporosis rats model. Different concentrations of Chinese wolfberry extract extracted with the use of water, and physiological saline were gavaged to rats, the related indicators were examined 70 d after the death of rat. The results showed that the Lycium barbarum extract could effectively improve the bone mineral density of osteoporosis rats up to 0.05 g/cm, conversion growth factor-beta 1 to 28.15 μg/mL, nitric oxide to 7.05 μmol/L, nitric oxide synthase to 8.23 U/mL, phosphorus ion to 0.05 mmol/L, and osteocalcin to 0.13 nmol/mL. Lycium barbarum extract can effectively reduce the serum calcium ion to 0.15 mmol/L, magnesium ion to 0.10 mmol/L, alkaline phosphatase to 13.17 U/L, immunoregulatory factor interleukin-6 to 12.75 ug/mL and tumor cell necrosis factf-alpha tot 1.06 ug/mL in rats with osteoporosis. Moreover, the concentration of Lycium barbarum extract increased inversely with the decrease of various indexes. It is concluded that Lycium barbarum extract can effectively regulate the cytokines in the body of osteoporotic rats, alleviate the osteolysis of rats, and achieve the goal of treating osteoporosis.
