A Thermal Synthesis of Yellow-green Carbon Dots as a Fluorescent Probe for the Study of the Pro-oxidation of Piceatannol
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Abstract:
In order to investigate the pro-oxidative activity of paclitaxel (Pic) in a cost-effective and time-saving manner, this study used o-phenylenediamine as the raw material for thermal synthesis of the yellow-green fluorescent carbon quantum dots (CDs). Then the CDs were characterized by UV-vis absorption spectrophotometry, fluorescence spectrophotometry, transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR), with their stability at different temperatures, pHs, ionic strengths, and exposure time lengths also studied. Finally, the Cu2+-catalyzed quenching effect of Pic on CDs fluorescence and the dose-response relationship were investigated. The results revealed that the CDs in aqueous solution had the optimum emission wavelength of 570 nm and optimum excitation wavelength of 385 nm, with an average diameter of 7.4 nm and a surface rich in functional groups such as amide bonds. The CDs exhibited strong resistance to photobleaching, low sensitivity to temperature and ionic strength, and good luminescence in pH 5~10. In the presence of Cu2+ at 100 μmol/L, the degree of fluorescence quenching was linear with the concentration of piceatannol in the range of 1.5~12.5 μmol/L. When the concentration of piceatannol was higher than 12.5 μmol/L, the decrease in the system’s fluorescence approached a plateau while the pro-oxidative effect of Pic was no longer obvious. This study can provide a theoretical basis for the practical application of piceatannol as a functional food.
