Effects of Water Extract of Poria on Helicobacter pylori Inhibition and GES-1 Cells Proliferation
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Abstract:
Inhibitory activity on Helicobacter pylori (Hp) of different water extracts of Chinese herb (Atractylodes rhizome, Poria, dried orange peel, Yam and polysaccharide complex (mixed water extracts of Atractylodes rhizome, Poria, dried orange peel and yam) was studied. The antibacterial experiment results showed that the water extract of Poria, polysaccharide complex and Atractylodes rhizome demonstrated a certain inhibitory activity on Hp. The inhibition rates were 93.29%, 62.85% and 47.14% at the concentration of 1000.00 μg/mL, respectively. The water extract of Poria showed the most significant effect. The water extract of Herb had different inhibitory effects on urease activity, and the water extract of Poria had the best effect (IC50=618.90 μg/mL). The water extract of Poria showed a dose-dependent effect on the inhibition of Hp. The inhibition rate was over 80% when the concentration reached 15.62 μg/mL or more. The survival rate of human gastric epithelial cells (GES-1) was significantly increased to 128.35% after treatment with 125.00 μg/mL of the water extract from Poria for 24 h. Therefore, the water extract of Poria might repair the Hp-injured stomach by inhibiting Hp proliferation and urease activity and promoting the proliferation of GES-1 cells.
