Effect of Lactobacillus plantarum ER135 on the Improvement of Depression Induced by Reserpine in Mice
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The improvement effect of Lactobacillus plantarum ER135 on depression induced by reserpine in mice was investigated. Male ICR mice (n=40, 6-week) were administered with L. plantarum ER135 strain suspension (2.0×1010 cfu/mL) by gavage for continuous 21 days, then all mice were injected with reserpine (4 mg/kg) at 22th day to establish depression model. The improvement effect of L. plantarum ER135 on the mice was evaluated by observing the changes of behavioristics phenomena of mice, detecting serum and tissue biochemical indicator as well as relevant protein expression changes in hippocampal tissue. Compared with the control group, after administration of L. plantarum ER135, the symptoms of hypothermia, blepharoptosis and decreased motor ability of these mice were significantly improved. Compared with the model group, the concentration of 5-hydroxytryptamine, dopamine and norepinephrine in brain tissue increased by 2.06 ng/L, 1.42 pg/L and 10.12 ng/L, respectively. The level of serum inflammatory factors decreased. Tumor necrosis factor and interleukin-1 beta decreased by 9.40 ng/l and 10.63 ng/L, respectively. It also reduced the level of oxidative stress (p<0.05, p<0.01). Western-blot results showed that L. plantarum ER135 significantly could incuce an increases of the expression of cAMP, CREB, BDNF and other key proteins in the hippocampal neurotrophic pathway of depressed mice. L. plantarum ER135 can relieve depression of mice induced by reserpine.
