Protective Effect of Caffeic Acid Phenylethyl Ester on Heart of Diabetic Mice
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Abstract:
The protective effect of caffeic acid phenylethyl ester (CAPE) on the heart of diabetic mice and its mechanism were investigated. Diabetes mellitus model was established in mice by subcutaneous intraperitoneal injection of streptozotocin and feeding high-fat and high-sugar diet. The mice were randomly divided into blank group, injury group and protection group. The protective group was given CAPE by gastric perfusion, the other two groups were given 0.9% saline by gastric perfusion. The changes of oxidative indexes in heart tissue of mice were detected to evaluate the protective effect of CAPE. After successful modeling, the contents of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT) in the injured group decreased by 0.00058 U/mg protein, 0.0033 mg/mL tissue and 20.95 U/mg protein in turn, respectively. The contents of malondialdehyde (MDA), protein carbonylation (PCO), nitric oxide (NO) in the protected group decreased by 0.126 mmol/mg protein, 3.205 mmol/mg protein and 0.5469 μmol/mg protein in turn after CAPE protection, respectively. Results indicated that high glucose environment could aggravate oxidative stress and induce oxidative damage in the heart, while CAPE could reduce the content of various indicators and the degree of injury. Increased oxidative stress might lead to diabetes mellitus. After CAPE treatment, the degree of injury in mice decreased, the antioxidant activity and the free radical scavenging ability were improved, resulting in their hearts potection.
