The Property of Chitosan with Different Microstructure/Starch Composite Material and Its Application
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Abstract:
In this study, four kinds of chitosan with different microstructures were chosen, and blended with starch to form the composite material. The rheological behavior, viscoelastic property and tensile property of composite material were investigated. Moreover, the releasing property of tablet coated with chitosan/starch composite material was analyzed by in vitro test. The results showed that chitosan/starch solution presented pseudoplastic behavior. The fluid shear-thinning behavior was enhanced as the viscosity average molecular weight of chitosan increasing. The tensile strength and elongation of composite film were improved due to the rearrangement of chitosan and starch chains during the preparation. In the in vitro releasing test, while transported to simulated intestinal fluid, a chitosan/starch gel-like layer was formed outside the coating tabletby the hydrogen bond between -NH3+ of chitosan and -OH of starch, which restricted the drug releasing. As viscosity average molecular weight of chitosan increasing, less drug released. The tablet coated by composite material with 2.543×105 g/mol molecular weight chitosan showed a well-controlled releasing property, with 70.59% drug releasing in simulated small intestine fluid (21.83%) and simulated colon fluid (48.77%).
