Protective Effect of Nephrotic Syndrome Rats with Total Flavonoids of Penthorum chinense Pursh
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Abstract:
To study the protective effect of total flavonoids from Penthorum chinense pursh on adriamycin-induced nephrotic syndrome model rats, in this article, the total flavonoids of Penthorum chinense pursh were used as materials, the rat model of nephrotic syndrome was induced by adriamycin. The amount of 24 h urine protein, body weight, organ index, triglyceride (TG), total cholesterol (TC), the total protein (TP), creatinine (Scr), urea nitrogen (BUN), albumin (ALB) content and renal tissue pathological changes were used as indicators to explore the effects of total flavonoids on nephrotic syndrome model rats. The results showed that the total dose of adriamycin was 5mg/kg, which was administered on the 1th d and 8th d respectively. The model was successfully established in 21 days. After 4 weeks of drugs intervention, compared with the model group, the TP in the high-dose group of total flavonoids increased by 9.86%, the TC decreased by 36.98%, the TG decreased by 30.77%, and the level of 24 h urine protein decreased by 70.84%. In the low-dose group of total flavonoids, the TP increased by 11.86%, the TG decreased by 19.79%, the 24 h urine protein level decreased by 57.98%, and the renal fibrosis and injury were significantly improved. The lipid metabolism in the rats model of nephrotic syndrome was regulated, the protein filtration of the kidney was improved, and the total flavonoids of Penthorum chinense pursh had a certain therapeutic effect on nephrotic syndrome.
