Effect of Lycium barbarum Polysaccharide on Gut microbiota in Allergic Asthmatic Mice
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Abstract:
The purpose of this study was to investigate the effect of Lycium barbarum polysaccharide (LBP) on intestinal flora in allergic asthmatic mice. Firstly, C57BL/6 mice were randomly divided into three groups: blank control group, allergic asthma model group and LBP intervention group. After 7 weeks of LBP intervention, routine status of mice was observed; pathological changes of lung tissue were detected by HE staining; and intestinal flora diversity was analyzed by 16 S rRNA sequencing. The results showed that after LBP intervention, the asthmatic performance of the mice was significantly relieved, and the degree of respiratory mitigation was mild, and there was no sputum purpura. To further investigate the mechanism, we detected the diversity of intestinal flora after LBP intervention. Sequencing and analysis showed that LBP intervention significantly changed the intestinal Firmicutes (p=0.0351) and Bacteroides (p=0.0015) in asthmatic mice, and significantly changed the genera of Lactobacillus (p=0.0105), Clostridium (p=0.0027), Bacteroides (p=0.0385) and Alistipes (p=0.0467). In conclusion, LBP improved allergic asthma and changed the composition of gut microbiota, which may enrich the knowledge of asthma pathogenesis and provide new prevention and treatment methods.
