Abstract:In order to investigate the current status of heavy metal pollution and food safety in different tissues and organs of Spinbarbus caldwelli farmed in Mengtangxi reservoir in Hunan province, atomic absorption spectrophotometry (AAS) was used to determine the contents of Pb, Cd, Cu, and Zn in the muscle, gill, fin, scales, skin, swim bladder, intestines, kidney, spleen, hepatopancreas, fat and brain of S. caldwelli. The results indicated that the content of Pb (2.90 mg/kg) was the highest in S. caldwelli hepatopancreas, which was less than 0.5 mg/kg in the other tissues or organs. The content of Cd was the highest in S. caldwelli kidney (3.54 mg/kg), followed by hepatopancreas (2.34 mg/kg), intestine (1.71 mg/kg), spleen (1.40 mg/kg) and gill (0.61 mg/kg), which was less than 0.1 mg/kg in the other tissues or organs. The content of Cu was less than 50 mg/kg in all the tissues and organs of S. caldwelli. The comprehensive pollution index (PI) of different tissues and organs of S. caldwelli were ranked as: kidney>hepatopancreas>intestines>spleen>gill>fin>brain>skin>scales>fat>muscle>swim bladder. Based on the maximum allowable consumption rate (CRLim) and target hazard quotients (THQ), the heavy metals in muscle of S. caldwelli farmed in Mengtangxi reservoir have no potential risk for consumers.