Study on Hypolipidemic Activity of Rosa roxburghii Tratt, Propolis and Crataegus Oral Liquid
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Abstract:
The aim of this work was to investigate the effect of oral liquid with Rosa roxburghii Tratt, propolis and Crataegus as main raw materials on hypolipidemic activity induced by diet-induced hyperlipidemia, the hyperlipidemic model mice were established by feeding high fat diet. The hyperlipidemia mice were divided into high-fat model group, Rosa roxburghii Tratt juice group, Rosa roxburghii Tratt propolis group, Rosa roxburghii Tratt Crataegus group, and Rosa roxburghii Tratt propolis Crataegus group, and each group received different Rosa roxburghii Tratt oral liquid for 28 days. The body weight and feed intake of the mice were measured during the gavage. Total cholesterol (TC), Triglyceride (TG), High-density Lipoprotein (HDL-C), Malondialdehyde (MDA) in serum and liver of mice were measured after 28 days feed. Results showed that the Rosa roxburghii Tratt oral liquid could effectively alleviate hyperlipidemia symptoms. The total cholesterol (TC) in the serum of the mice administrated with the Rosa roxburghii Tratt propolis Crataegus oral liquid was significantly reduced by 23.94% (p<0.05), serum triglyceride (TG) was significantly reduced by 46.41%(p<0.05), and the MDA content in serum was significantly reduced by 73.83% (p<0.05). These indicated that the Rosa roxburghii Tratt propolis Crataegus oral liquid had good hypolipidemic effect and could effectively delay the rate of lipid peroxidation.
