Abstract:This study compared the antioxidant effects of three Enteromorpha products processed with different processing methods in a mouse model. Aged mice were administrated by gavage with enteromorpha original (EO, 300 mg/kg·d), enteromorpha polysaccharide (EP, 100 mg/kg·d), low dose of enteromorpha ultrasound (EU-L, 300 mg/kg·d) or high dose of enteromorpha ultrasound (EU-H, 350 mg/kg·d). The contents of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), catalase (CAT) in serum, liver and brain tissues of mice were analyzed after 7 weeks. The results showed that all these enteromorpha products had no effect on the weight gain of the mice. The serum CAT content in model group was 6.90 U/mL, which was significantly (p<0.01) lower than to those for the EP group (8.79 U/mL), EU-L group (8.31 U/mL) and EU-H group (9.43 U/mL). The contents of SOD, GSH-Px and CAT in serum, liver and brain tissues of the EU-H were significantly (p<0.01) higher than the model group. The MDA contents of the four groups fed with enteromorpha products were lower (p<0.05) than that of the model group：9.94 U/mL, 7.88 U/mg prot, 6.63 U/mg prot (p<0.05).These results indicate that EU-H effectively improved the activities of antioxidant enzymes in the aged mouse model with the rate of reversing aging over 90%，showing advantages over EP; According to the comparison on dose, EU could increase the antioxidant effect on aged mice in a dose-dependent manner.
