Comparison of the Prevention and Treatment of Alcoholic Liver Injury in Mice from 8 Kinds of Chinese Medicine Decoctions
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Abstract:
In this article, Chinese medicines herbs with best protective effect on alcoholic liver injury were screened from eight kinds of Chinese medicines. Alcoholic liver injury model was established by intragastric administration of 56° red star Erguotou wine (12 mL/kg·bw) for 10 days. The drunken time and sobering time of mice, serum aspartate aminotransferase (AST) and Glutamic-oxalacetic transaminase (ALT) levels were determined. Meanwhile, HE staining were performed to observe pathological changes in liver tissue. Compared with pre-administration, the drunken times of Chuanxiong rhizoma, Schisandrae chinensis fructus and glycyrrhizae groups were respectively prolonged by 75.64% (p<0.05), 73.87% (p<0.05) and 153.58% (p<0.001). The sobering times of the Chuanxiong rhizoma, Schisandrae chinensis fructus, Puerariae lobatae radix, fios puerariae, Hovenia acerba，glycyrrhizae and Scutellariae radix groups were respectively shortened by 75.04% (p<0.001), 67.95% (p<0.001), 71.39% (p<0.01), 60.84% (p<0.001) and 75.26% (p<0.01), 80.48% (p<0.001),and 54.83% (p<0.05). Compared with the model group, the ALT levels of Chuanxiong rhizoma, Paeoniae radix alba, Puerariae lobatae radix, fios puerariae, glycyrrhizae and Scutellariae radix group were respectively decreased by 22.78% (p<0.001), 27.84% (p<0.001), 14.31% (p<0.01), 20.68% (p<0.01), 12.14% (p<0.05), 20.81% (p<0.01), and AST levels in paeoniae radix alba, and Puerariae lobatae radix were respectively decreased by 14.71% (p<0.05) and 12.69% (p<0.05). The pathological results showed that the hepatocyte edema and necrosis of Chuanxiong rhizoma, paeoniae radix alba, Puerariae lobatae radix, fios puerariae, glycyrrhizae and scutellariae radix were significantly reduced, and the degree of hepatocyte lesions was alleviated. The present study showed that among the eight Chinese medicines, Chuanxiong, radix paeoniae alba and radix puerariae had a better protective effect against alcoholic-induced liver injury. Moreover, Chuanxiong rhizoma also had effect for treating hangover and preventing drunkenness.
