Antialcoholism Effects of Rosa roxburghii Tratt Oral Liquid in Acute Drunkenness Mice
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Abstract:
The antialcoholism effects and liver protection of Rosa roxburghii Tratt oral liquid in acute drunkenness mice were investigated. Anti-alcoholic experiment: Each group was established as an acute drunkenness model after all mice were administered corresponding samples for 30 days. After 1 hour, the blood and liver tissue were taken. Compared with the serum ethanol concentration, the levels of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in liver issues in different groups of mice; Liver protection experiment: The blood and liver tissue were taken after modeling. The liver index, the contents of superoxide dismutase (SOD) and glutathione (GSH) in the liver, and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined. The results showed that compared with the model group, the high-dose group of Rosa roxburghii Tratt baverage decreased the serum ethanol concentration by 33.54%. It also increased the levels of ADH and ALDH, from 26.92 U/mL to 41.78 U/mL and 118.12 U/mL to 146.72 U/mL, respectively. The serum ALT and AST contents decreased by 58.40% and 42.69%, respectively, the liver index reduced by 9.80%, and the SOD content in liver issue increased by 72.65%, the GSH content increased by 25.34% (p<0.05). It indicates that Rosa roxburghii Tratt oral liquid has the function of relieving alcohol and has obvious protective effect on acute alcohol-induced hepatic injury.
