Effects of β-Casomorphin-7 on the Renal Function of Aged Mice
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Abstract:
The possible effects of β-Casomorphin-7 on renal function in aged mice were investigated. Fifty male Kunming mice were treated with 0.90% saline and low, moderate and high doses of β-Casomorphin-7. After continuous intragastric administration for 30 days, serum and tissue samples of all mice were collected for testing. Histopathological studies showed that β-Casomorphin-7 had a certain improvement effect on kidney tissue aging in aged mice. However, it seemed that the renal edema swelling in the high dose group was not alleviated and the epithelial cells were necrotic shedding. Compared with the model group, serum creatinine (CRE) levels, total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and glutathione peroxidase in the middle dose group of mice (GPx) activity were increased by 22.16%, 69.02%, 71.26% (p<0.05) and 24.41%, respectively, while the corresponding values in the high dose group were increased by 13.12%, 64.88%, 67.33% (p<0.05) and 17.90%, respectively. These suggested that β-Casomorphin-7 can regulate renal function and increase its antioxidant capacity in aged mice, but it is not dose-dependent. In addition, compared with the model group, the MDA levels of the mice treated with the low and moderate doses of β-Casomorphin-7 were decreased respectively by 15.40% and 3.17%, but increased by 16.08% in high-dose group. It indicated that the oxidation of the kidneys in the high-dose group of mice was aggravated. The results suggest that β-Casomorphin-7 may improve the renal dysfunction in aged mice. It may improve the aging damage by improving the antioxidant capacity. However, it seems to increase the kidney burden and cause other disease with the excessive intake of β-Casomorphin-7.