Synergistic Antioxidant Activity of Coptidis with Ginseng
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Abstract:
The study compared the scavenging effects and synergies of the combinations of Coptis extract (CE) and Ginseng extract (GE) with different mass ratios on the ABTS and DPPH free radicals. The obtained data for the combinations were analyzed using the drug combined analysis software "CompuSyn" to achieve the related parameters. In the ABTS reaction system, the IC50 values of CE and GE were 170.18±5.20 and 1615.73±40.17 μg/mL, respectively, while the IC50 values of the CE-GE combinations with the mass ratios of 4:1, 2:1, 1:1, 1:2 and 1:4 were 88.86±9.31, 209.12±9.56, 329.42±10.29, 188.39±6.33 and 31.42±7.52 μg/mL, respectively. According to the combined index (CI) values, CE and GE at a ratio of 4:1, 2:1 or 1:4 exhibited synergistic effects. In the DPPH reaction system, the IC50 values of CE and GE were 67.57±9.68 and 1590.86±21.35 μg/mL, respectively, while the IC50 values of the CE-GE combinations with the mass ratios of 4:1, 2:1, 1:1, 1:2 and 1:4 were 49.48±12.56, 195.04±7.58, 129.27±15.14, 404.07±10.55 and 153.11±6.32 μg/mL, respectively. According to the combined index (CI) values, CE and GE at a ratio of 4:1 and 1:4 exhibited synergistic effects. CE and GE worked synergistically to scavenge the ABTS and DPPH free radicals.
