Effect of Stems and Buds of Alisma orientalis on Blood Lipid in Rats with Hyperlipemia
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Abstract:
The regulating effect of Stems and Buds of Alisma orientalis on blood lipid in hyperlipidemia rats was investigated. Sixty male SD rats were fed with high-fat diet for a certain period of time to establish a rat model of hyperlipidemia. At the same time, different doses of Stems and Buds of Alisma Orientalis were administered by intragastric administration. Biochemical tests were performed to observe total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein (LDL-C) in serum of rats in different groups at different times, and at the end of experiment HE staining was used to observe the histopathological changes of the liver of each group. The results showed that for the high and low dose groups of Stems and Buds of Alisma orientalis, the levels of TC and LDL-C in serum were significantly decreased on the 14th day of modeling. Compared with the model group, the TC decreased by 16.64% and 12.85%, respectively (p<0.05); The LDL-C decreased by 29.90% and 22.98%, respectively (p<0.05). On the 21st day of modeling, the levels of TC and LDL-C in the high and middle dose groups decreased. On the 28th day of modeling, there was no significant difference compared with the model group. Stems and Buds of Alisma orientalis has a certain effect of lowering blood lipids in the early stage of high fat formation. The results of HE staining showed that there was some cell degeneration in the hepatocyte tissue of the model group. Compared with the model group, the liver tissue of the rats in the drug-administered group had a certain degree of improvement. It can be seen that the Stems and Buds of Alisma orientalis has a certain effect on lowering blood lipids.
