Antioxidant Activity of Mulberry Alkaloid in Mice on High-fat Diet
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Abstract:
To study the antioxidant capacity of mulberry alkaloid in mice on high fat-diet, the mice on high fat-diet were fed with alkaloid at different concentrations (20, 40, 80 mg/kg) by gastric gavage for 4, 8, 12, 16 weeks respectively, the content of malondialdehyde (MDA) and other indicators in liver and serum of the mice on high fat-diet were assessed by kit. The results showed that in the mice fed with a dose of 80 mg/kg by gastric gavage for 16 weeks, the content of MDA in liver decreased by 43.63% and in serum decreased by 50.91%, compared with the hyperlipidemic control group. The contents of T-AOC and GSH in liver were increased by 2.36 and 2.69 times respectively, and the contents in serum increased by 2.25 and 1.59 times respectively. The activity of glutathione (GSH), catalase (CAT), peroxidase (POD), glutathione peroxidase (GSH-Px) and superoxide dismutase(SOD) in liver increased by 1.82, 2.22, 1.90 and 1.22 times, and the activity in serum increased by 1.48, 2.19, 1.59 and 1.44 times, respectively. In conclusion, the alkaloids of mulberry leaves have strong antioxidant effects on high-fat diet mice.
