Protective Effect of Urtica fissa on Kidney Injury in Type 2 Diabetic Mice
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Abstract:
The study is about the protective effect of Urtica fissa on kidney injury in type 2 diabetic mice and its relationship with antioxidant activity. The model of type 2 diabetes mellitus in mice was established by intraperitoneal injection of streptozotocin (STZ). Diabetic mice were randomly divided into model group, metformin group (0.14 g/kg), low, medium and high dose group of Urtica fissa (0.25 g/kg, 0.50 g/kg, 1.00 g/kg). Mice were given saline for 4 weeks. The levels of serum urea nitrogen (BUN), creatinine (SCr) and malondialdehyde (MDA) and protein carbonyl (PCO) in kidney tissue were measured. The activity of superoxide dismutase (SOD) and catalase (CAT) were measured and the pathological changes of kidney were observed. The results showed that compared with the model group, serum BUN and SCr decreased by 6.15 mmol/L and 30.87 μmol/L (p<0.05), renal MDA decreased by 2.97 nmol/mg, PCO decreased by 23.43 nmoL/mg (p<0.05, p<0.01), SOD activity increased by 55.85 U/mg and CAT activity increased by 33.84 U/mg (p<0.01), and alleviate the pathological state of kidney tissue in a dose-dependent manner. It can be concluded that Urtica fissa has protective effect on STZ-induced kidney injury in type 2 diabetic mice, and the protective mechanism is related to antioxidant effect.
