Protective Effect of Caffeic Acid Phenylethyl Ester on Pancreas of Diabetic Rats
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Abstract:
The protective effect of caffeic acid phenethylester (CAPE) on pancreas of type 2 diabetic rats and their mechanism were investigated. Thirty male SD rats were randomly divided into three groups: blank group, injury group and protection group. The rat model of type 2 diabetes mellitus was induced by high-fat and high-sugar diet combined with streptozocin (STZ). The protective group was protected by CAPE. The contents of malondialdehyde (MDA), protein carbonylation (PCO), nitric oxide (NO), glutathione (GSH) and activities of super oxide dismutase (super oxide dismutase), catalase (CAT) in pancreas were determined. The results showed that the contents of MDA, PCO and NO in the injured group were significantly increased, which were 2.52, 1.64 and 2.78 times higher than those in the blank group, respectively, while the contents of MDA, PCO and NO in the protective group were lower than those in the injured group, only 47%, 69% and 47% of the injured group, respectively. It indicated that diabetes can lead to oxidative stress of pancreas and destroy its structure and function. Protecting with CAPE could decrease the contents of MDA, PCO and NO and reduce the damage to pancreas. The activities of SOD, CAT, GSH and other antioxidants in the body were reduced by excessive free radicals produced by the body in response to oxidative stress. CAPE could enhance the activities of SOD, CAT and GSH and accelerate the speed of scavenging free radicals in the body. It had certain protective effect on diabetic pancreas.
