The Study of Anti-alcoholism Effect and Protecting Liver by Sober-up Drink of Gardenias in Temulentia Mice
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Abstract:
In order to investigate the sobering effects of the different doses of sobering drinks and the protection of alcohol-induced liver injury on temulentia mice, the abilities of rods and runners, biochemical and histological examinations of blood, liver and kidney were compared . The results showed that the number of drops and level of climbing in low and high dose groups were less than those in model group (p<0.05), and the first drop time and climbing time were longer than those (p<0.05). Compared with model group, the vacuolar degeneration was reduced, the cell swelling and inflammation were lessened, and the renal tubular water degeneration of kidney was decreased in the drug-administered group. And the values of AST were diseased by 33.13% and 29.54%, as well as the values of ALT were reduced by 39.41% and 38.91% in low and middle dose groups. The content of SOD was increased by 30.34% in high dose group, and the administered groups had less influence on CYP2E1. The findings indicated that the sobering drink has a certain sobering effect on temulentia mice, and has certain protective effects on alcohol-induced live injury in mice.
