Aloe Polysaccharide Combined with Fructose-oligosaccharide in the Treatment of Alcoholic Liver Injury in Mice
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Abstract:
The protective effects of aloe polysaccharide combined with fructose oligosaccharide on liver injury induced by chronic alcohol in mice were investigated. Aloe polysaccharide combined with fructose oligosaccharide was used to protect mice from chronic alcoholic liver injury. The liver index of mice was measured. Serum biochemical indexes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC) and triglyceride (TG), and liver biochemical indexes such as reduced glutathione (GSH), superoxide dismutase(SOD), glutathione peroxidase (GSH-PX), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6), were analyzed to to evaluate the protective effect of aloe polysaccharide combined with fructose oligosaccharide on liver in mice. The histopathological changes were also observed. The results showed that aloe polysaccharide combined with fructose oligosaccharide could significantly decrease ALT、AST、TCand TGto (23.37±0.80) U/L, (106.50±4.58 ) U/L (2.85±0.10) mmol/L, (1.38±0.12) mmol/L, and increase the antioxidant enzyme GSH、SOD、GSH-Px inliver to (93.65±4.93), (61.24±3.13) and (82.75±7.04) U/(mg pro) (p<0.05), respectively. However, the levels of IL-6 and TNF- α decreased to (28.24 ±0.45) and (155.90±9.67) pg/(mg pro), respectively. The protective effect of liver in high dose group was more obvious than that of silythistle. Its main protective mechanism was antioxidation. Therefore, this work provided a theoretical support for Aloe polysaccharide combined with fructose oligosaccharide compound to alleviate alcoholic liver injury.
