Analysis of Potential Risk Factors for Cassia tora Seed Extract
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Abstract:
This paper mainly reviews the efficacy and adverse reactions of Cassia tora seed consumption found in recent years, and analyzes the major components and their contents in Cassia tora seed. The main potential risk factors screened included anthraquinones, phytosterols and their oxides, and alkaloids. Emphasis was placed on the analysis of these potential risk factors, including their properties, structure and safety. Anthraquinones such as emodin have a planar, rigid structure and can significantly inhibit the activity of L-02 cells. Phytosterols have similar structure to cholesterol, are easily oxidized to produce persistent organic pollutants (POPs) that are similar to harmful COPs., which can significantly inhibit the activity of HepG2 cells. Oral administration of adenine also caused significant acute toxicity in rats. Finally, prospects of the toxicological research on Cassia tora seed extract were presented, along with the need to set up in vitro toxicological evaluation model, dose-response model and structure-toxicity model for developing a basic toxicological database and an early warning system to assess the safety of health food products and safety limits.
