Study on the Hypolipidemic Effect of Zhi Qing Shuang Healthy Tea
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Abstract:
This paper was to study the hypolipidemic effect of Zhi Qing Shuang (ZQS) in rats and cells, which provided a reference for the development of health food with hypolipidemic effect. The animal experiment was carried out according to evaluation method of auxiliary hypolipidemic function. During the experiment, 60 rats were used in this study, of which 10 rats as the normal group were given normal feed. The remaining rats were given high-fat feed, according to the TC level, which were randomly divided into model group, positive control group and ZQS (high, middle and low dose) group. Each group was normally fed for 4 weeks, the groups were given ZQS (high, middle and low dose) and positive drug, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were determined after the last gavage administration by collecting the blood of orbit. For in vitro cell experiment, the hyperlipidemia model was established in hepG2 cells which was induced by sodium oleate. The hypolipidemic effect was evaluated by comparing the content of TC, TG between model group and drug group. Compared with the model group, the results showed that ZQS induced a significant reduction in TC, TG and LDL-C levels, with the largest reduce rates of 34.52%, 43.22% and 44.89%, respectively. The content of HDL-C was significant increased up to 50.62% in high dose of ZQS group. The in vitro cell experiment results demonstrated that ZQS induced a significant reduction in TC, TG, with the largest reduce rates of 27.54%, 27.98%. In conclusion, ZQS has the function of reducing blood lipid. The study lays a foundation for the development and application of ZQS health food.
