Effects of Camel Colostrum on Cyclophosphamide-induced Immunodeficiency in Mice
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Abstract:
In this paper, the effect of camel colostrum on immune function in immunocompromised mice was investigated. A 30-day gavage experiment using Kunming mice was performed to explore the immune regulation of camel colostrum on cyclophosphamide (CY)-induced immunodeficiency and immune injury by immunological parameters. The mice were fed with camel colostrum and casein to calculate the food conversion rate and protein efficacy ratio of camel colostrum. The percentage of positive lymphocyte and the count of white blood cells in the high dose group of colostrum were 2.2 times and 1.4 times higher than those in the immunocompromised group, respectively (p<0.05). Medium and high dose of camel colostrum can significantly increase CD4+/CD8+ ratio, IgG level (p<0.05), phagocytic capacity and immune organ index of macrophage in immunocompromised mice. Moreover, camel colostrum can effectively repair the damage of immune organs in mice. The protein utilization rate of camel colostrum is 85.05%, and the corrected protein efficacy ratio is 3.17. In conclusion, camel colostrum has the effect of enhancing immune function in immunocompromised mice. Camel colostrum protein is a high-quality protein that is more easily absorbed to exert immunoregulatory functions. In addition, camel colostrum could be a promising, potent immunomodulatory therapeutic agent for various immune disorders.
