The Research Progress of Magnetic Relaxation Switch Technology in Biological Detection Applications
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The research progress of magnetic relaxation switch technology in biological detection applications was introduced in this paper.The magnetic relaxation switch detection technology is a rapid detection technology with high sensitivity, good specificity and strong anti-interference ability combing nuclear magnetic resonance technology, nanotechnology with immunoassay technology. The magnetic nanoparticles modified with the biological ligand are used as magnetic resonance probe, which can identify a substance specifically.When specifically combined with the analyte,themagnetic nanoparticles change from dispersed state to aggregated state, the transverse relaxation time (T2) of the Water proton is changed to realize the detection of the analyte.At present, magnetic relaxation switch detection technology has been widely used in the detection of biomolecules such as proteins, microorganisms, nucleic acids, and small molecules, and has made some achievements.In addition, the magnetic relaxation switch detection technology based on magnetic signal has strong anti-interference ability and is suitable for complex component detection,which makes the technology has a broad application prospect in food safety, environmental detection, clinical diagnosis and other fields.
