Toxicological Safety Evaluation of the Powered Flower of Bombax malabaricum
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Abstract:
To assess the safety of Morinda citrifolia for long-term oral administration and provide the basis of the toxicological safety for future intake. A 90-day feeding trial was conducted using the acute toxicity test，the Ames test, the micronucleus test of bone marrow cells in mice and the sperm shape abnornality test of the national food safety standard. The maximal tolerated dose (MTD) for oral administration of powdered Bombax flower by the male and female mice were＞80.00 g/kg body weight (BW). The results of the three genetic tests, the Ames test,the micronecleus test of bone marrow cells in mice and the sperm shape abnormality test in mice, were all negative. After 90 days of feeding, the food intake and food utilization rate of the high-dose group different from the normal control group, but no significant difference was detected in other indices; the low and medium dose group of SD rats caused insignificant differences in the body weight, food intake, food utilization rate,hematology, blood biochemistry, organ weight and relative ratio of organ to body from the normal control group. No significant changes in biological meaningfulness were found in the major organ coefficients and histopathological examinations. The results obtained in the current research showed that long-term intake of kapok is safe for humans in a dose of less than 40.0 g/kg BW.
