L-arabinose Promotes the Growth and Development of Caenorhabditis elegans and Reduces Fat Synthesis
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Abstract:
In this work, the effect of L-arabinose on the growth development and fat synthesis capacity of Caenorhabditis elegans was investigated. Glucose was used as control sample while 2.5, 5.0, 10.0 and 20.0 mmol/L of L-arabinose were added respectively as treatment groups. After pretreatment of synchronized, the head swing frequency, body bending frequency, body length, number of offspring, triglyceride content and oil red O staining of elegans were analyzed. The results showed that L-arabinose had no significant effect on the body bending frequency and number of offspring of Caenorhabdits elegans. However, it had a significant efficiency on the head swinging frequency and body growth of elegans. When the concentration was 20 mmol/L, the head swining frequency increased by 20%. When the concentration of L-arabinose was 7.5 mmol/L, the body length of elegans increased by 11%. The triglyceride analysis revealed that the contents of triglyceride in treatment groups were lower than that of control group and decreased gradually with increasing L-arabinose concentrations. When the concentration was 20 mmol/L, the triglyceride content in elegans reduced by nearly 67% compared with the control group. The results of oil red O staining were consistent with the analysis of triglyceride. Results indicated that L-arabinose can promote the head swining frequency and body growth of Caenorhabdits elegans and has obvious effect on reducing fat synthesis of them, thus has a certain lipid-lowering function.
