Inhibition of Bel-7402 Human Hepatoma Cells and H22 Tumor-bearing Mice by Maca Alkaloids
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Abstract:
The effects of maca alkaloid on the anti-hepatocarcinoma activity of Bel-7402 cells in vitro and the anti-H22 liver cancer activity in vivo were investigated. Maca alkaloid crude extract was obtained by 0.5% hydrochloric acid and 95% ethanol solvents, and maca alkaloid was further purified by acid dissolution and alkali precipitation method. The anti-hepatocarcinoma activity of maca alkaloids was determined by MTT method and the anti-H22 liver cancer activity in vivo. The cell experiments showed that maca alkaloids of different doses exhibited an anti-liver cancer activity towards Bel-7402 cell, and the decreasing order of the activity was maca alkaloids high-dose group > maca alkaloids middle-dose group > maca alkaloids low-dose group. The in vivo anti-liver cancer results showed that maca alkaloids at high or middle doses had a significant anti-liver cancer activity. The results demonstrated that maca alkaloids exhibit an anti-liver cancer activity, which would provide a new direction for the study of maca alkaloid activity.
