Effect of Mixture of Safflower and Flaxseed Oil on Blood Glucose in Diabetic Mice
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Abstract:
The investigate the intervention of mixture of safflower and flaxseed oil on blood glucose in diabetic mice was investigated. A mouse model of diabetes was established using streptozotocin (STZ), and the mice were randomly divided into five groups (high blood glucose control group, safflower oil group, linseed oil group, linseed oil extract group, mixture of safflower and flaxseed oil group, 12 in each group, half male and half female). The mice were given the test samples in groups for 14 days. After 30 min of the last administration, mice were given 2 g/kg of glucose by gavage, the blood glucose was measured at 10 min, 30 min, 60 min, 90 min, and 120 min, respectively, and the relative value of area under blood glucose curve (AUC) in mice, pancreatic β-cell function (HOMA-β) and islet resistance index (HOMA-IR) were obtained. The results showed: There was a significant difference (p<0.05) in blood glucose concentration 30 min after meal in mice of mixture of safflower and flaxseed oil group (15.73 mmol/L) and high blood glucose control group (17.38 mmol/L). Therefore, compound oil of safflower seed and flaxseed could reduce AUC and increase insulin secretion and sensitivity of target cells to insulin in diabetic mice.
