Hypoglycemic, Hypolipidemic and Antioxidant Activities of Doellingeria scaber Total Flavonoids in Diabetic Mice
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Abstract:
The effects of Doellingeria scaber total flavonoids on the hypoglycemia, blood lipid and oxidation in diabetic mice were investigated. Alloxan-iduced diabetic mice were fed with Doellingeria scaber total flavonoids, flavonoids and polysaccharide at the dose of 50 mg/kg, 100 mg/kg, 200 mg/kg, respectively, for 4 weeks. The amount of water, food intake and body weight changes were recorded. The results showed that the total flavonoids can reduce the fasting blood glucose (Glu), improve the glucose tolerance, and effectively relieve the "a little" sanduo symptoms. The total flavonoids can also effectively regulate the serum TC, TG, LDL- C, HDL-C concentrations. As compared with model group, the HDL - C value of the experimental group increased by 44.6%, while the TG, TC and LDL-C values were reduced by 18.7% , 27.4% and 24.8%, respectively. Furthermore, the total flavonoids can reduce the content of MDA in liver tissue, increase the content of gsh-px and CAT, SOD, enhance its antioxidant capacity. These effects may be associated with improved antioxidant capacity and improved lipid metabolism in diabetic mice.
