The Improvement of Blood Lipid in Type Ⅱ Diabetic Rats by Pterostilbene and its Modulation of PPARγ Expression
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Abstract:
The effects of pterostilbene (PTE) on blood lipid and PPAR γ expression of adipose tissues in type Ⅱ diabetic rats were investigated. Rats were randomly divided into five groups: normal control group, type Ⅱ diabetes mellitus (T2DM) group, PTE low dose group, PTE middle dose group and PTE high dose group. Blood lipid, the activity of SOD and the level of MDA were examined, and PPARγ mRNA and protein expression in adipose tissue were evaluated. As compared to normal rats, the levels of TG, TC, LDL-C and MDA in the T2DM group increased, while the level HDL-C and SOD decreased. The level of TG in PTE (low, middle and high) groups and TC, LDL-C and MDA in PTE (low and middle) groups were lower than those in the T2DM groups , while the activity of SOD in PTE (low and middle) groups was higher than the T2DM group (p < 0.05). As compared with normal rats, the mRNA and protein expression of PPARγ significantly decreased. Moreover, the mRNA and protein expression of PPARγ significantly increased in PTE rats as compared to the T2DM rats. Therefore, PTE can improve the the level blood lipid and mediate the state of oxidative stress, and the underlying mechanism might be associated with the regulation of PPARγ expression.
