Protection of Proanthocyanidins on Kidney in Diabetic Rats
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
This study aims to explore the protective effect of Proanthocyanidins (PC) on diabetic rats kidney and potential mechanism. In this work, the diabetic rats model was established by feeding with a high fat and sugar diet in combination with a streptozotocin treatment. Animals were randomly divided into three groups: model group, test group (PC, 150 mg/kg) and normal group. After 4 weeks of treatment, blood glucose, total cholesterol (TC), triglyceride (TG) and kidney malondialdehyde (MDA), protein carbonyl (PCO), superoxide dismutase activities (SOD) and catalase (CAT) activities were determined. Results showed that as compared with the normal group, TC and TG in the model group were significantly increased by 4.02-fold and 6.88-fold (p < 0.01), while the SOD and CAT activities in the kidney tissue were significantly (p < 0.01) decreased by 27.88% and 17.61%, respectively. The levels of MDA and PCO increased significantly by 51.10% and 81.36% (p < 0.01). As compared with the model group, the blood glucose, TC and TG levels in the experimental group were significantly reduced by 50.84%, 55.70% and 70.52%, respectively (p < 0.01). The activities of SOD and CAT in kidney tissues were significantly increased by 26.05% and 12.97% (p < 0.01), and the contents of MDA and PCO in kidney tissues were significantly decreased to 21.54% and 11.86% l, respectively (p < 0.01). The pathologic slice revealed that PC pretreatment could reduce STZ-induced pathological damage such as glomerular atrophy. These results demonstrated that PC may exhibit a protection on diabetic rats kidney, and the underlying mechanism might be related to its anti-oxidative properties and free radical scavenging abilities.
