Removal of Cd (Ⅱ) from mouse model by EDTA-chitosan
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Abstract:
Cadmium pollution through the food chain is a serious threat to human health, and it is thus of great significance to explore safe and effective ways to remove cadmium from organisms. In this paper, chitosan derivatives (ETC) were prepared via acylation with EDTA. The stability of ETC was characterized using TG-DSC technique. A mouse model of Cd contamination was established by intraperitoneal injection of 1 mg/kg CdCl2, according to two continuous and discontinuous exposure processes. The removal of cadmium in mice was determined when exposed to ETC, EDTA, and chitosan (CTS). The eyeballs were excised from living body. Heart, liver and kidney were excised by sacrificed mice. To track the cadmium in mice, the cadmium contents in blood, eyeball, liver, kidney, and heart were determined. The results showed that there were significant differences in the body weight and acute toxicity effects of different exposure methods on mice. The cadmium removal rates on the blood of EDTA, ETC, and CTS were 58.94%, 51.68%, and 37.43%, respectively. The removal rate of cadmium in mouse organs by ETC was much higher than that by other cadmium removal agents. The removal rates of cadmium in hearts and kidneys by ETC were 63.90% and 45.00%, respectively. The results provide a reference for the removal of heavy metals using chitosan derivatives.
