Abstract:Antrodia camphorata has a variety of beneficial physiological activities, this study is intended to through animal experiments to explore the antialcoholism effects and liver protection of laboratory homemade Antrodia camphorata oral Liquid. Compared with the tolerance time and drunken time, the levels of serum alanine aminotransferase and aspartate aminotransferase, the levels of alcohol dehydrogenase and acetaldehyde dehydrogenase in liver homogenates in different groups of mice, it was found that the high-dose Antrodia camphorata oral liquid could significantly prolong the time of intoxication tolerance in mice, from 14.1 ± 5.2 min to 27.9 ± 7.9 min, shorten the time of intoxication from 230.0±22.3 min to 161.7±38.0 min. It can significantly reduce serum aspartate aminotransferase and alanine aminotransferase caused by alcohol injury, from 56.34±9.60 U/L to 42.35±12.29 U/L and 69.57±11.88 U/L to 51.86±15.04 U/L, respectively. It could also further increase of the level of alcohol dehydrogenase and acetaldehyde dehydrogenase, from 6.21±1.91 U/mg prot to 9.82±3.36 U/mg prot and 454.15±119.18 U/mg to 454.15±119.18 U/mg, respectively. It shows that the homemade oral liquid has anti-alcohol and liver protection effects.
