Improvement of Memory and Learning Ability of Mice by Secondary Metabolites of Galactomyces geotrichum
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Abstract:
This work reported that the ethyl acetate extract of secondary metabolites of endophytic fungus Galactomyces geotrichum could improve the memory and learning ability of mice. With D-galactose-induced the Alzheimer's disease (AD) mice as the model, the influence of different levels of dosages of the extract on the contents of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and malondialdehyde (MDA) in serum, liver and brain of the mice was investigated, using the Morris water maze test. The activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) in mice brain were also evaluated. The results showed that the escape latent period of the mice in each dose group was significantly shortened(p<0.05), and there was also noticable improvement in the spatial probe capability of the mice. Compared with the model group, the activities of SOD, GSH-Px and CAT in serum, liver and brain tissue of the low, middle and high dose groups were increased, while the MDA content decreased, the activity of AchE decreased, as well as that of ChAT increased in brain tissue. The findings indicated that the ethyl acetate extract of secondary metabolites could improve the memory and learning ability of the AD mice.
