This study evaluated the edible safety of health food Hehui capsule. According to the National Health and Family Planning Commission's (2003 edition) and (GB15193.1-2014), the rat acute toxicity test, genotoxicity test (micronucleus test of bone marrow cells, sperm abnormality test and Ames test in mice) and feeding test of 30 days in rats were carried out to observe if there was toxic reaction. The results showed that the maximum tolerated dose (MTD) of male and female rats to Hehui capsule was higher than 15.0 g/kg·bw in acute toxicity test, so the Hehui capsule was nontoxic; The results of micronucleus test of bone marrow cells, sperm malformation test and Ames test in mice were all negative, Hehui capsule had no genotoxicity; In the 30-day feeding test of rats, the dose of Hehui capsule was within the range of 1.20 g/kg·bw ~ 4.80 g/kg·bw (the maximum dose was equal to 100 times the recommended dose of the human body). There were no significant adverse effects on the test of relevant indicators in the growth, development, hematology, blood biochemistry and pathology of rats. It showed that Hehui capsule had no acute toxicity, genetic toxicity and subacute toxicity, and had high food safety.
