Comparative Study on the Protective Effect of 18α, β-Glycyrrhizic Acid Monomer on the Alcoholic Liver Injury
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Abstract:
The protective effect of 18α-glycyrrhizic acid and 18β-glycyrrhizic acid on the alcohol liver injury was investigated in this study. The SD rats were randomly divided into four groups: normal control group, model control group, 18α-glycyrrhizic acid group and 18β-glycyrrhizic acid group. Except for the normal group, each group was administered intragastrically with 40% alcohol, and the administration group was administered intragastrically with 18α-glycyrrhizic acid and 18β-glycyrrhizic acid once daily for 4 weeks. At the end of the 4th week, an oral glucose tolerance test (OGTT) was performed. After the administration, all rats were sacrificed, and the blood and liver samples were collected for the detection of biochemical index, liver function, and liver histopathology. Compared with model group, 18α-glycyrrhizic acid and 18β-glycyrrhizic acid had significant effects on improving liver function and antioxidant indexes. Moreover, treatment with 18β-glycyrrhizic acid significantly improved the metabolism of glucose, lipid and protein. The results of pathological sections showed that 18α-glycyrrhizic acid and 18β-glycyrrhizic acid all had better protective effects on hepatocytes. Therefore, 18α-glycyrrhizic acid and 18β-glycyrrhizic acid had good protective effects on the alcoholic liver injury, among which 18β-glycyrrhizic acid was superior to 18α -glycyrrhizic acid in modulating metabolism of glucose, lipid and protein.
