Effects of Fermented Barley Extracts on the Fat Deposition of Caenorhabditis elegans
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Abstract:
The effects of Lactobacillus plantarum dy-1 fermented barley extracts (LFBE) and its major bioactive components on the fat deposition of Caenorhabditis elegans (C. elegans) were investigated in this study. Firstly, the obesity model of C.elegans was established, and then they were fed with different concentrations of extracts and main bioactive components, and the changes of fat content in nematode were analyzed by oil red O staining. The results showed that LFBE could significantly reduce the fat deposition of C. elegans compared with the model group, , which decreased by 26% at the concentration of 1600 μg/mL, and the body fat content of the model group tended to be normal, while the unfermented barley (RBE) showed no the same effect. Total protein, polysaccharide and polyphenol compounds isolated from LFBE had different effects on reducing fat deposition. The fat deposition of C. elegans decreased by 39%, 26% and 12% at the phenolic compounds, protein and polysaccharide concentrations of 16 μg/mL, 480 μg/mL and 480 μg/mL, respectively. In conclusion, LFBE could significantly inhibit the accumulation of fat in C. elegans and the phenolic compounds were particularly effective in reducing fat deposition.
