Hepatoprotective and Hypoglycemic Effects of Antrodia camphorata Obtained by Medium Optimization and Its Functional Beverage
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The hepatoprotective and hypoglycemic effects of Antrodia camphorata powder obtained by medium optimization and its functional beverage on alcohol-induced acute liver injury mice and streptozotocin (STZ)-induced diabetic mice were investigated in this study. Antrodia camphorata powder could significantly reduce the serum levels of ALT, AST, and MDA (p<0.01), and significantly increase the activities of SOD, CAT, and GSH-Px to alleviate the liver injury (p<0.05 or p<0.01). Meanwhile, both the pretreatment of Antrodia camphorata powder and its functional beverage could significantly decrease the levels of fasting glucose, glucose tolerance, TG, TC, and LDL significantly, and could increase the level of HDL significantly (p<0.05 or p<0.01). Through investigating the energy metabolic pathways, Antrodia camphorata powder and its functional beverage could improve the glucose and lipid metabolism of diabetic by down-regulating the phosphorylation levels of AMPKα and AKT in the liver. Therefore, Antrodia camphorata powder had obvious functions to protect against alcohol-induced acute liver injury and STZ-induced hyperglycemia in mice, which might be achieved by anti-oxidative stress and the regulation of energy metabolism related factors, and could be developed as a functional beverage for relieving alcoholism, protecting liver, and reducing blood glucose in the future.
