Therapeutic Effect of Burdock Root Extract BP1 on the Type Ⅱ Diabetic Rats
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Abstract:
In order to study the therapeutic effect of burdock root extract BP1 on the diabetic rats, the wistar diabetic rats were fed with acarbose 200 mg/kg, 0.9% of the normal saline, 400 mg/kg, 600 mg/kg and 800 mg/kg burdock root extract BP1, respectively. The mortality, body weight and fasting blood glucose of each group were monitored weekly. After 9 weeks, the rats were dissected and blood biochemical parameters were measured. The pancreas of the kidney was paraffin-embedded and HE stained. In addition, part of renal tissue was used for fluorescent quantitative PCR. The results showed that the burdock root extract BP1 could restore the body weight of diabetic rats to a certain extent, regulate serum lipids and reduce the fasting blood glucose in diabetic rats. The electron microscopic observation showed that BP1 could significantly increase insulin secretion granules in pancreatic islet β cells. In addition, BP1 could promote the expression of IL-18 and TNF-α, and reduce the kidney injury in diabetic rats; the oxidative damage of kidney and pancreas in diabetic rats can be improved by increasing the activity of SOD enzyme. In conclusion, the burdock root extract BP1 had a protective effect on the kidney pancreas organ.
